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Cat Health News Blog

A resource for dedicated cat supporters

Since its start in 2007, Cat Health News has featured the latest information on feline health. The bi-weekly blog is a mix of the most current published research from Winn-funded research and other sources. There are over 875 blog post items and more than 1,000 subscribers through the RSS feed.


icon-blogWinn-funded research is specifically noted by the small green cat.

  • Gabapentin sedation in cats with and without chronic kidney disease

    Mar 31, 2020
    icon-blog   MT17-002    Investigation of the pharmacokinetics of gabapentin sedation in cats with and without chronic kidney disease. (A Winn-funded grant project interim progress report)

    Principal Investigator: Jessica Quimby, DVM, PhD, DACVIM; Ohio State University

    adorable-angry-animal-animal-portrait-208984In this study, normal cats have completed the full pharmacokinetic (PK) study at 20 mg/kg and the limited sampling pharmacokinetic study at 10 mg/kg. Sixteen chronic kidney disease (CKD cats) - (ten IRIS Stage 2, twelve IRIS Stage 3) - have completed the limited sampling PK study at 10 mg/kg. Samples from eight CKD cats have been analyzed to date to test the model. The model performed well and the data for normal cats demonstrated that half-life was similar to previous published reports. For the limited sampling portion of the study, the median half-life of gabapentin in normal cats is similar. In contrast, CKD cats had significantly higher median calculated half-life after the single 10 mg/kg dose. The investigators are currently still enrolling CKD cats with the goal of including additional early IRIS stage 2 cats and IRIS Stage 4 cats. One feline medicine exclusive practice has been recruited to provide an additional enrollment location for the project. The investigator plans to conclude this portion of the study in time to submit a future ACVIM or AAFP abstract. 

    Presentations: 

    The data from the normal cat PK study was presented as an oral abstract at AAFP Annual Conference in San Francisco, November 2019: 

    Pharmacokinetics of Single Dose Gabapentin for Stress Relief in Normal Cats 

    Jessica M. Quimby, Luke A. Wittenburg, Turi K. Aarnes, Karina J. Creighton, Karen A. VanHaaften, Rene E. Paschall, Sarah E. Jones, Emily M. King, Clara E. Bruner, Jessica N. Wallinger. The Ohio State University, Columbus, OH, USA and University of California-Davis, Davis, CA, USA. 

    Summary prepared for Winn Feline Foundation © 2020

    Download a pdf of this summary

    See also:

    Guedes AGP, et al. Assessment of the effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life in osteoarthritic geriatric cats.
    J Am Vet Med Assoc. 2018 Sep 1;253(5):579-585. 


    van Haaften KA, et al. Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. J Am Vet Med Assoc. 2017 Nov 15;251(10):1175-1181

     


    gabapentin stress behavior chronic kidney disease research sedation

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